FKBP (FK506-binding protein) FK506-binding proteins

Inhibitor/Activator

Cat.No.	Name	Information
M21320	SAFit2	SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51) with a Ki value of 6 nM. SAfit2 has been used as a potential agent in the study of major depression, obesity, and chronic pain.
M9704	Shield-1	Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)
M55893	dTAGV-1 hydrochloride	dTAGV-1 hydrochloride is the hydrochloride form of dTAGV-1 that is a small molecule degrader of FKBP12.
M53982	Suc-Ala-Leu-Pro-Phe-pNA	Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a substrate of FK-506 binding protein (FKBP).
M41343	RapaBlock	RapaBlock is a potent, non-immunosuppressive and brain-impermeable FKBP12 ligand.
M41342	FKBP51F67V-selective antagonist Ligand2	FKBP51F67V-selective antagonist Ligand2 is a potent FKBP51 F67V-selective antagonist ligand.
M31001	dTAGV-1-NEG TFA	dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12F36V-selective degrader.
M29056	AP1867	AP1867 is a synthetic FKBP12F36V-directed ligand.
M28764	SAFit1	SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM.