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SEN177

Cat. No. M11437
SEN177 Structure
Synonym:

azol-3-yl)piperidin-1-yl]pyridine;SEN 177;SEN177;SEN177;SEN 177

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Quality Control
Biological Activity

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 338.38
Formula C18H19FN6
CAS Number 2117405-13-5
Purity
Solubility N/A
Storage at -20°C
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Keywords: SEN177, azol-3-yl)piperidin-1-yl]pyridine;SEN 177;SEN177;SEN177;SEN 177 supplier, inhibitors

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