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SCH 23390 hydrochloride

Cat. No. M7279
SCH 23390 hydrochloride Structure
Synonym:

R-(+)-SCH23390 hydrochloride

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 125  USD125 In stock
25mg USD 275  USD275 In stock
50mg USD 510  USD510 In stock
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Quality Control & Documentation
Biological Activity

SCH 23390 hydrochloride is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). SCH 23390 hydrochloride is also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). SCH 23390 hydrochloride blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.

The repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%). This treatment also increases the production rates of dopamine D1 receptors in the striatum (+44%) and substantia nigra (+54%).

Chemical Information
Molecular Weight 324.24
Formula C17H18ClNO.HCl
CAS Number 125941-87-9
Solubility (25°C) Water 30 mg/mL (with gentle warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dopke, et al. J Pharmacol Exp Ther. AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography.

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