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Sc-236 is a COX-2 specific inhibitor with an IC50 value of 10 nM for COX-1 and a PPARγ agonist with oral activity. Sc-236 inhibits activator protein-1 (AP-1) activity by c-Jun amino terminus. Sc-236 exerts anti-inflammatory effects by inhibiting ERK phosphorylation in mouse models.
| Molecular Weight | 401.79 |
| Formula | C16H11ClF3N3O2S |
| CAS Number | 170569-86-5 |
| Form | Solid |
| Solubility (25°C) | DMSO: ≥20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related COX Products |
|---|
| Firocoxib
Firocoxib is a selective COX-2 inhibitor exhibiting high selectivity to inhibit COX-2. |
| Ampiroxicam
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory compound. |
| Bufexamac
Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM. |
| Carprofen
Carprofen inhibits canine COX2 with IC50 of 0.03 mM. |
| Diclofenac Diethylamine
Diclofenac diethylamine is a nonsteroidal anti-inflammatory compound taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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