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SB-668875

Cat. No. M8150

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SB-668875 Structure

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Quality Control & Documentation
Biological Activity

SB-668875 is a novel, selective peptide agonist at OX2 orexin receptors. SB-668875 possesses advantages over Orexins A and B which are equipotent at OX2 orexin receptors. The orexins can cause direct and reversible depolarisation of the postsynaptic membrane. The rank order of potencies of orexin receptor agonists to excite serotonergic DRN neurones is orexin-A = orexin-B > SB-668875-DM. In contrast, the rank order of potency of these agonists to excite noradrenergic locus coreleus (LC) neurones is orexin-A > orexin-B > SB-668875-DM.

Chemical Information
Molecular Weight 2857.26
Formula C120H206N44O35S
CAS Number 274252-40-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ellen M Soffin, et al. Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus

[2] Ellen M Soffin, et al. Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus

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  Catalog
Abmole Inhibitor Catalog




Keywords: SB-668875 supplier, inhibitors, activators

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