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S(-)-Propranolol hydrochloride

Cat. No. M20993
S(-)-Propranolol hydrochloride Structure

Hemangeol, Inderal

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Biological Activity

(S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.

Chemical Information
Molecular Weight 295.8
Formula C16H22ClNO2
CAS Number 4199-10-4
Solubility (25°C) DMSO 59 mg/mL
Water 59 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Xue Ma, et al. J Pharm Biomed Anal. Novel chiral metal organic frameworks functionalized composites for facile preparation of optically pure propranolol hydrochlorides

[2] Jidong Yang, et al. Talanta. Effects of (R)- and (S)-propranolol hydrochloride enantiomers on the resonance Rayleigh scattering spectra with erythrosine B as probe and their analytical applications

[3] Limei Chen, et al. J Chromatogr Sci. Semipreparative enantiomer separation of propranolol hydrochloride by high-performance liquid chromatography using cellulose tris(3,5-Dimethylphenylcarbamate) chiral stationary phase

[4] Xin Wang, et al. Chirality. Solubility, metastable zone width, and racemic characterization of propranolol hydrochloride

[5] M Bartolomei, et al. J Pharm Biomed Anal. Physico-chemical characterisation of the modifications I and II of (R,S) propranolol hydrochloride: solubility and dissolution studies

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Keywords: S(-)-Propranolol hydrochloride, Hemangeol, Inderal supplier, Adrenergic Receptor, inhibitors, activators

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