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(S)-JNJ-54166060 

Cat. No. M28719
(S)-JNJ-54166060  Structure
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Biological Activity

(S)-JNJ-54166060 is an enantiomer of JNJ 54166060. JNJ 54166060 is a potent P2X7 antagonist.

Chemical Information
Molecular Weight 438.81
Formula C20H15ClF4N4O
CAS Number 1627900-42-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuxian Li, et al. ACS Appl Mater Interfaces. Study on the Performance of Oxygen-Rich Zn(O,S) Buffers Fabricated by Sputtering Deposition and Zn(O,S)/Cu(In,Ga)(S,Se)2 Interfaces

[2] Martin Fieder, et al. Biodemography Soc Biol. Effects of wife's and husband's income on wife's reproduction: an evolutionary perspective on human mating

[3] Peter J Morone, et al. Oper Neurosurg (Hagerstown). Craniometrics and Ventricular Access: A Review of Kocher's, Kaufman's, Paine's, Menovksy's, Tubbs', Keen's, Frazier's, Dandy's, and Sanchez's Points

[4] Feiran Wu, et al. J Hand Microsurg. Finkelstein's Test Is Superior to Eichhoff's Test in the Investigation of de Quervain's Disease

[5] Thierry Peyrard, et al. Transfusion. Anti-U-like as an alloantibody in S-s-U- and S-s-U+(var) black people

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Keywords: (S)-JNJ-54166060  supplier, P2 Receptor, inhibitors, activators

 
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