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S 24795

Cat. No. M8445

All AbMole products are for research use only, cannot be used for human consumption.

S 24795 Structure

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Biological Activity

S 24795 is a selective partial agonist for the α7-subtype of nicotinic acetylcholine receptor (nAChR). S 24795 was shown to be effective at improving learning and memory in various animal models relevant to Alzheimer’s disease and age-related memory loss, and is used in investigating the roles of α7 nAChRs in aging, learning, memory, and cognition.

Chemical Information
Molecular Weight 418.07
Formula C14H13BrNO · I
CAS Number 304679-75-2
Solubility (25°C) Water: 1 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] No authors listed. J Neurosci. Expression of Concern: Wang et al., "Dissociating β-Amyloid from α7 Nicotinic Acetylcholine Receptor by a Novel Therapeutic Agent, S 24795, Normalizes α7 Nicotinic Acetylcholine and NMDA Receptor Function in Alzheimer's Disease Brain"

[2] Hoau-Yan Wang, et al. S 24795 limits beta-amyloid-alpha7 nicotinic receptor interaction and reduces Alzheimer's disease-like pathologies

[3] Hoau-Yan Wang, et al. Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain

[4] Laura Lagostena, et al. The partial alpha7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus

[5] Gretchen Lopez-Hernandez, et al. Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons

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