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(S)-2-Aminohexanedioic acid

Cat. No. M39567
(S)-2-Aminohexanedioic acid Structure
Size Price Availability Quantity
1g USD 30  USD30 In stock
5g USD 90  USD90 In stock
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Biological Activity

(S)-2-Aminohexanedioic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Information
Molecular Weight 161.16
Formula C6H11NO4
CAS Number 1118-90-7
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Haoli Mao et al. Front Endocrinol (Lausanne). High preoperative blood oxaloacetate and 2-aminoadipic acid levels are associated with postoperative delayed neurocognitive recovery

[2] Roderick C Slieker et al. Nat Commun. Identification of biomarkers for glycaemic deterioration in type 2 diabetes

[3] Shuangyuan Wang et al. Cell Rep Med. Amino acids, microbiota-related metabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study

[4] Hongqiao Lin et al. Free Radic Biol Med. Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo

[5] H Bräuner-Osborne et al. J Med Chem. A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid

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