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Antioxidant and anti-ischemic agent. Also inhibits mitochondrial permeability transition, prevents the early step in apoptosis by preventing collapse of the electrochemical gradient across the mitochondrial membrane. IC50 for in vitro lipid peroxidation is 0.3 μM. IC50 for carnitine palmitoyltransferase (CPT-1) in heart homogenate is 16.8 μM. The shift from fatty acid to glucose oxidation may contribute to anti-ischemic effect.
| Molecular Weight | 776.93 |
| Formula | C31H48N2O4S · 2 C4H4O4 |
| CAS Number | 148913-55-7 |
| Solubility (25°C) | DMSO: soluble 16 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Hakan Erdoğan, et al. The Effects of Difumarate Salt S-15176 after Spinal Cord Injury in Rats
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