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RU7

Cat. No. M8134

All AbMole products are for research use only, cannot be used for human consumption.

RU7 Structure

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Biological Activity

RU7 is a selective inhibitor of bacterial β-clamp interaction with DNA polymerase POL III, and an inhibitor of a DNA polymerase sliding clamp. Sliding clamps are proteins which function with diverse DNA polymerases, repair factors, and cell cycle-control proteins. RU7 binds to the peptide-binding pocket of the β-clamp and selectively inhibits Pol III, compared with Pol II and Pol IV.

Chemical Information
Molecular Weight 497.18
Formula C14H11Br2NO5S2
CAS Number 355400-87-2
Solubility (25°C) DMSO: ≥20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kenta Mori, et al. Highly Active Cross-Metathesis of Tetrafluoroethylene with a Seven-Membered N-Heterocyclic-Carbene-Ruthenium Catalyst

[2] Aleksandra Bjelosevic, et al. Synthesis, characterisation and biological activity of the ruthenium(II) complexes of the N 4-tetradentate (N 4-T L), 1,6-di(2'-pyridyl)-2,5-dibenzyl-2,5-diazahexane (picenBz 2)

[3] Kai Xiong, et al. Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II

[4] Nicholas F Dupuis, et al. Tests of Kramers' Theory at the Single-Molecule Level: Evidence for Folding of an Isolated RNA Tertiary Interaction at the Viscous Speed Limit

[5] Eugen Waldt, et al. Structural evolution of small ruthenium cluster anions

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Keywords: RU7 supplier, inhibitors, activators

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