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RSM-932A

Cat. No. M30694

All AbMole products are for research use only, cannot be used for human consumption.

RSM-932A Structure
Synonym:

TCD-717

Size Price Availability Quantity
5mg USD 180  USD180 In stock
10mg USD 300  USD300 In stock
25mg USD 640  USD640 In stock
50mg USD 920  USD920 In stock
100mg USD 1250  USD1250 In stock
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Quality Control & Documentation
Biological Activity

RSM-932A (TCD-717) is a specific ChoKα inhibitor with IC50s of 1 and 33 μM for human recombinant ChoKα and ChoKβ enzymes, respectively. RSM-932A acts as the “first in humans” compound targeting ChoKα. RSM-932A is potent in vitro anti-proliferative and in vivo anti-tumoral activity against human xenografts in mice, showing high efficacy with low toxicity profiles.

Chemical Information
Molecular Weight 877.53
Formula C46H38Br2Cl2N4
CAS Number 850807-63-5
Form Solid
Solubility (25°C) DMSO 16.67 mg/mL (ultrasonic and warming and heat to 60°C)
Storage 4°C, protect from light, dry, sealed
References

[1] Tahl Zimmerman, et al. Sci Rep. Identification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae

[2] Juan Carlos Lacal, et al. Mol Cancer Ther. Preclinical characterization of RSM-932A, a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells

[3] Tahl Zimmerman, et al. Antimicrob Agents Chemother. Antiplasmodial activity and mechanism of action of RSM-932A, a promising synergistic inhibitor of Plasmodium falciparum choline kinase

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Keywords: RSM-932A, TCD-717 supplier, inhibitors, activators

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