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RS 17053 hydrochloride is a α1A-adrenoceptor antagonist, with very high affinity for α1A receptors (pKi and pA2 estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α1B and α1D subtypes (pKi and pA2 estimates 7.7 - 7.8).
| Molecular Weight | 449.42 |
| Formula | C24H29N2O2Cl.HCl |
| CAS Number | 169505-93-5 |
| Solubility (25°C) | DMSO 22.47 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Bunney, et al. A review Arch Gen Psychiatry. Norepinephrine in depressive reactions.
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