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Roseoside

Cat. No. M19325
Roseoside Structure
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Biological Activity

Roseoside is a compound isolated from the leaves of Elaeocarpus japonicus.

Chemical Information
Molecular Weight 386.44
Formula C19H30O8
CAS Number 54835-70-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Le Tran Nguyen Vu, et al. Nat Prod Res. Prenylated flavonoids and other constituents from Macaranga indica

[2] Eun Young Hong, et al. Molecules. Inhibitory Effects of Roseoside and Icariside E4 Isolated from a Natural Product Mixture (No-ap) on the Expression of Angiotensin II Receptor 1 and Oxidative Stress in Angiotensin II-Stimulated H9C2 Cells

[3] Jairo Bermdez, et al. Nat Prod Commun. (6R,9S)-6"-(4"-hydroxybenzoyl)-roseoside, a new megastigmane derivative from Ouratea polyantha and its effect on hepatic glucose-6-phosphatase

[4] Yumiko Yamano, et al. Chem Pharm Bull (Tokyo). Synthesis of optically active vomifoliol and roseoside stereoisomers

[5] Y Murai, et al. Planta Med. Absolute configuration of (6S,9S)-roseoside from Polygonum hydropiper

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