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RORγt inverse agonist 31

Cat. No. M42604

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RORγt inverse agonist 31 Structure

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Quality Control & Documentation
Biological Activity

RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM.

Chemical Information
Molecular Weight 555.36
Formula C23H15Cl2F3N4O3S
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Bin Jiang et al. Bioorg Med Chem Lett. Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists

[2] Matteo Dal Prà et al. Bioorg Med Chem. Targeting RORs nuclear receptors by novel synthetic steroidal inverse agonists for autoimmune disorders

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Keywords: RORγt inverse agonist 31 supplier, ROR, inhibitors, activators

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