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Robenidine Hydrochoride

Cat. No. M20435
Robenidine Hydrochoride Structure
Synonym:

Dexium, Nugatex, Rasexinium, Toraxine

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Quality Control & Documentation
Biological Activity

Robenidine hydrochloride is an anticoccidial agent mainly for poultry.

Chemical Information
Molecular Weight 370.66
Formula C15H14Cl3N5
CAS Number 25875-50-7
Solubility (25°C) DMSO 74 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Clarissa A Jung, et al. Vet Anim Sci. Alternatives to robenidine to control gastrointestinal disorders of weaner rabbits in the field

[2] Alina Krollenbrock, et al. ACS Infect Dis. Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum

[3] FEEDAP, et al. EFSA J. Safety and efficacy of Robenz® 66G (robenidine hydrochloride) for chickens for fattening and turkeys for fattening

[4] Yikun Mei, et al. Front Microbiol. FDA Approved Drug Library Screening Identifies Robenidine as a Repositionable Antifungal

[5] Rebecca J Abraham, et al. J Med Chem. Robenidine Analogues as Gram-Positive Antibacterial Agents

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Keywords: Robenidine Hydrochoride, Dexium, Nugatex, Rasexinium, Toraxine supplier, Anti-infection, inhibitors, activators


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