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RMM 46 is a mSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.
| Molecular Weight | 450.5 |
| Formula | C24H26N4O5 |
| CAS Number | 1307896-46-3 |
| Solubility (25°C) | DMSO 45.05 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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