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Rimtuzalcap (CAD-1883) is the first (first-in-class), selective small conductance calcium-activated potassium channel (SK channel) positive allosteric regulator. Rimtuzalcap can be used in the study of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA).
| Molecular Weight | 378.42 |
| Formula | C18H24F2N6O |
| CAS Number | 2167246-24-2 |
| Solubility (25°C) | DMSO ≥ 200 mg/mL |
| Storage | 2-8℃, protect from light, dry, sealed |
| Related Potassium Channel Products |
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| Palmitoyl-L-carnitine chloride
Palmitoyl-L-carnitine chloride (L-Palmitoylcarnitine chloride) is a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. Palmitoyl-L-carnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. |
| VU0810464
VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC50=165 nM) and GIRK1/4 (EC50=720 nM) channels with improved brain penetration. |
| QO 58
QO 58 is a potent modulator of K(v)7 channels. |
| NS3623
NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. |
| ML67-33
ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. |
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