All AbMole products are for research use only, cannot be used for human consumption.
Rimonabant Hydrochloride (SR 141716A) is a potent and selective cannabinoid CB1 receptor antagonist (Ki = 1.98 nM). Rimonabant Hydrochloride also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (IC50 = 48 nM). Rimonabant Hydrochloride displays no activity at CB2 receptors. Rimonabant Hydrochloride (SR 141716A) reduces food intake and body weight in orally dosed non-obese Wistar rats.
Neuron. 2020 Feb 19;105(4):621-629.e4.
Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits.
Rimonabant Hydrochloride purchased from AbMole
 |
Source | Neuron (2020 Feb). Figure 3. SR 141716A (Abmole Bioscience) |
| Method | sIPSC assay | |
| Cell Lines | mice | |
| Concentrations | 10 μM | |
| Incubation Time | 1h | |
| Results | Inhibiting CB1R with SR at ZT0 increased inhibitory transmission to ZT12 levels, while SR had no effect at ZT12. |
| Molecular Weight | 500.25 |
| Formula | C22H21Cl3N4O.HCl |
| CAS Number | 158681-13-1 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cannabinoid Products |
|---|
| UCM707
UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of Anandamide. |
| SCH 336
SCH 336 is a potent, selective, inverse and orally active CB2 agonist. |
| JTE-907
JTE-907 is a highly selective, orally active CB2 receptor inverse agonist and exerts anti-inflammatory effects in vivo. |
| LEI-101
LEI-101 is a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist, with a pEC50 of 8 for hCB2, and a pKi of less than 4 for hERG. |
| AEF0117
AEF0117 is a signaling-specific inhibitor of the cannabinoid receptor 1 (CB1-SSi). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
