All AbMole products are for research use only, cannot be used for human consumption.
RF9 is a selective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). RF9 displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors. RF9 blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo. RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate.
| Molecular Weight | 482.62 |
| Formula | C26H38N6O3 |
| CAS Number | 876310-60-0 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL Water ≥ 10 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Neuropeptide Receptor Products |
|---|
| CYM2503
CYM2503 is a putative GalR2-positive allosteric modulator. |
| BIBO3304 diTFA
BIBO3304 (diTFA) is an orally effective and selective neuropeptide Y (NPY) Y1 receptor antagonist. |
| BIBO3304 free base
BIBO3304 free base is a nonpeptide neuropeptide Y Y1 receptor antagonist. |
| BMS-193885 L-Lactic acid
BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. |
| Neuropeptide Y (human, rat, mouse) TFA
Neuropeptide Y (human, rat, mouse) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
