All AbMole products are for research use only, cannot be used for human consumption.
Rezafungin acetate is a novel echinocandin-based antifungal agent with potent antifungal activity against Candida, Aspergillus and Pneumocystis. Rezafungin has higher stability and greater solubility in plasma, aqueous and buffered solutions.
Rezafungin exerted its fungicidal effect by specifically binding to β-( 1,3)-glucan synthase and inhibiting β-( 1,3)-glucose synthesis, thereby preventing fungal cell wall formation. The minimum inhibitory concentrations (MIC90) of Rezafungin against 90.0% of wild and fluconazole-resistant strains of Candida albicans, Candida smoothis and Candida tropicalis were 0.06, 0.12 and 0.03 mg/L, respectively.
The 10-days survival rate of Rezafungin (2 mg/kg; single dose administration) treatment in mice with disseminated infection of Aspergillus fumigatus was 100%, which was significantly higher than that of the blank control (20.0%), and comparable to the effect of 3 mg/kg single dose intraperitoneal injection of amphotericin B.
| Molecular Weight | 1285.44 |
| Formula | C65H88N8O19 |
| CAS Number | 1631754-41-0 |
| Solubility (25°C) | DMSO >100 mg/mL |
| Storage | 4°C, dry, sealed |
| Related Anti-infection Products |
|---|
| BTZ043 Racemate
BTZ043 Racemate (BTZ038, BTZ044) is a decaprenylphosphoryl-b-D-ribose 2-epimerase inhibitor. |
| Enoxacin
Enoxacin is a small molecule inhibitor of binding between the B2-subunit of vacuolar H+-ATPase (V-ATPase) and microfilaments. |
| Posaconazole
Posaconazole is a sterol C14α demethylase inhibitor with IC50 of 0.25 nM. |
| Pretomanid
Pretomanid (PA-824) is a novel, orally active nitroimidazole derivative with antimycobacterial activity for use in tuberculosis-related studies. |
| Clofazimine
Clofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
