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Rehmannioside A

Cat. No. M18733
Rehmannioside A Structure
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5mg USD 400  USD400 In stock
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Biological Activity

Rehmannioside A is an iridoid glucoside extracted from the roots of Rehmannia glutinosa.

Chemical Information
Molecular Weight 524.47
Formula C21H32O15
CAS Number 81720-05-0
Solubility (25°C) DMSO > 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chen Fu, et al. J Ethnopharmacol. Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

[2] Min Gu, et al. Chin J Nat Med. A combined quality evaluation method that integrates chemical constituents, appearance traits and origins of raw Rehmanniae Radix pieces

[3] Lingxiao Chen, et al. J Pharm Biomed Anal. Decoding active components in a formulation of multiple herbs for treatment of psoriasis based on three cell lines fishing and liquid chromatography-mass spectrometry analysis

[4] Hui Yang, et al. Biopharm Drug Dispos. Exploring the compatibility mechanism of ShengDiHuang Decoction based on the in situ single-pass intestinal perfusion model

[5] Miao Sun, et al. Biomed Pharmacother. Rehmannioside A attenuates cognitive deficits in rats with vascular dementia (VD) through suppressing oxidative stress, inflammation and apoptosis

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