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Refanezumab

Cat. No. M24583

All AbMole products are for research use only, cannot be used for human consumption.

Refanezumab Structure
Synonym:

GSK249320

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Quality Control & Documentation
Biological Activity

Refanezumab (GSK249320) is an IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab can cross the blood-brain barrier (BBB) in animal stroke models. Refanezumab has the potential for the enhancement of recovery of function poststroke.

Chemical Information
CAS Number 1233953-61-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Steven C Cramer, et al. Stroke. Proof-of-Concept Randomized Trial of the Monoclonal Antibody GSK249320 Versus Placebo in Stroke Patients

[2] Scott Barbay, et al. Stroke. Effects of postinfarct myelin-associated glycoprotein antibody treatment on motor recovery and motor map plasticity in squirrel monkeys

[3] Steven C Cramer, et al. Stroke. Safety, pharmacokinetics, and pharmacodynamics of escalating repeat doses of GSK249320 in patients with stroke

[4] B Abila, et al. Clin Pharmacol Ther. First-time-in-human study with GSK249320, a myelin-associated glycoprotein inhibitor, in healthy volunteers

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Keywords: Refanezumab, GSK249320 supplier, inhibitors, activators

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