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Recombinant Rat SDF-1/CXCL12 (E. coli)

Cat. No. M43958

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Rat SDF-1/CXCL12 (E. coli) Structure
Synonym:

Stromal-Cell Derived Factor-1 alpha; CXCL12 alpha

Size Price Availability Quantity
10ug USD 350  USD350 In stock
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Quality Control & Documentation
  • Purity: >97%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

SDF-1 also known as CXCL12 is belonging to the CXC chemokine family. SDF-1 binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. SDF-1/CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the postnatal organism.

A DNA sequence encoding (Lys22-Lys89) was expressed.

The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml.


Accession: Q9QZD1

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 7.9 kDa

Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 150 mM NaCl.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Mingfang Ao, et al. Cancer Res. Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium

[2] Ravindra Kodali, et al. Cardiovasc Res. Chemokines induce matrix metalloproteinase-2 through activation of epidermal growth factor receptor in arterial smooth muscle cells

[3] Ghazal Banisadr, et al. Eur J Neurosci. Highly regionalized distribution of stromal cell-derived factor-1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons

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Keywords: Recombinant Rat SDF-1/CXCL12 (E. coli), Stromal-Cell Derived Factor-1 alpha; CXCL12 alpha supplier, Cytokines and Growth Factors, inhibitors, activators

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