Genus: Rat
Expression system: E.coli
Purity: >95% as determined by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight; 11.3 KDa
Storage and Stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Recombinant sample aliquots are stable for 3 months at <-20°C.
Bioactivity: Protein S100-A8 (Mrp8) contains 2 EF-hand structural domains and belongs to the S-100 family. mrp8 binds two calcium ions per molecule and has an affinity similar to that of S-100 proteins. s100 proteins are localized in the cytoplasm and/or nucleus of a variety of cells and are involved in regulating a number of cellular processes, such as cell cycle progression and differentiation. the S100 gene includes at least 13 members, which are located as a cluster on chromosome 1q21. It may function as an inhibitor of casein kinase and as a cytokine. Altered expression of this protein has been associated with cystic fibrosis disease.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] H Y Sroussi, et al. J Dent Res. S100A8 triggers oxidation-sensitive repulsion of neutrophils
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