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Recombinant Rat Interferon-gamma (CHO-expressed)

Cat. No. M10297
Recombinant Rat Interferon-gamma (CHO-expressed) Structure
Synonym:

rRtIFN-γ; IFN-γ, Rat (CHO-expressed)

Size Price Availability Quantity
10ug USD 72  USD80 In stock
50ug USD 144  USD160 In stock
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Quality Control
  • Current batch:
  • Purity >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Rat Interferon-gamma (IFN-γ, Rat) also known as Type II interferon or immune interferon, is a cytokine produced primarily by T-lymphocytes and natural killer cells. IFN-γ signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-γ–induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-γ is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers. Mature IFN-γ exists as noncovalently-linked homodimers. It shares high sequence indentity with mouse IFN-γ (86 %). IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. Additionally, IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95%, Endotoxin < 0.2 EU/μg
Solubility Water
Saline
PBS
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Recombinant Rat Interferon-gamma (CHO-expressed), rRtIFN-γ; IFN-γ, Rat (CHO-expressed) supplier, Cytokines, inhibitors

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