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Recombinant Rat IL-4 Protein (CHO, C-His)

Cat. No. M40612

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Rat IL-4 Protein (CHO, C-His) Structure
Synonym:

Interleukin-4; BCGF-1; B cell stimulatory factor-1

Size Price Availability Quantity
5ug USD 166  USD166 In stock
25ug USD 320  USD320 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. Interleukin-4 is produced by mast cells, T cells, and bone marrow stromal cells. It is a key regulator in hormone control and adaptive immunity. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells.

Measured in a proliferationassay using C6 cells, the ED50 is < 0.2 μg/ml.


Accession: P20096

Apparent Molecular Weight: 18~22 kDa, reducing conditions

Endotoxin < 0.2 EU/μg

Lyophilized after extensive dialysis against PBS.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C.
References

[1] Ying Xiao et al. Front Immunol. Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7

[2] Hiroai Okutani et al. Glia. Recombinant interleukin-4 alleviates mechanical allodynia via injury-induced interleukin-4 receptor alpha in spinal microglia in a rat model of neuropathic pain

[3] Peter Brock et al. Scand J Gastroenterol. Interleukin-4 gene transfer into rat pancreas by recombinant adenovirus

[4] Yang Cao et al. J Allergy Clin Immunol. IL-4 induces production of the lung collectin surfactant protein-D

[5] G Deretzi et al. J Autoimmun. Nasal administration of recombinant rat IL-4 ameliorates ongoing experimental autoimmune neuritis and inhibits demyelination

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Keywords: Recombinant Rat IL-4 Protein (CHO, C-His), Interleukin-4; BCGF-1; B cell stimulatory factor-1 supplier, Cytokines and Growth Factors, inhibitors, activators

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