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Recombinant Murine Midkine

Cat. No. M10286
Recombinant Murine Midkine Structure
Synonym:

rmMK; rm-midkine

Size Price Availability
5ug USD 166.5  USD185 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >97%, Endotoxin <1EU/μg
  • COA
  • MSDS
Biological Activity

Midkine is a heparin-binding growth factor, which contains 121 amino acid residues with 5 disulfide bonds. Midkine promotes the growth, survival, and migration of various cells, and plays roles in neurogenesis and epithelial mesenchymal interactions during organogenesis. The C-terminal portion contains the heparin-binding domain and the antigenicity and neurite-promoting sequences. Both the C- and N-terminals are necessary for the molecule′s neurotrophic effects.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >97%, Endotoxin <1EU/μg
Solubility Water
Saline
PBS
Storage at -20°C
References

The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18)
Ludwig T Weckbach, et al. Blood. 2014 Mar 20;123(12):1887-96. PMID: 24458438.

Midkine enhances fibrinolytic activity of bovine endothelial cells
S Kojima, et al. J Biol Chem. 1995 Apr 21;270(16):9590-6. PMID: 7721890.

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  Catalog
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Keywords: Recombinant Murine Midkine, rmMK; rm-midkine supplier, Cytokines, inhibitors

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