Recombinant Murine BMP-4 Protein is a TGF-beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. Mouse BMP-4 shares 85% aa sequence identity with mouse BMP-2 and 35%-54% with other mouse BMPs. BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (11, 12). The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans.
Determine its activity by ATDC-5 cells induced production of alkaline phosphatase, the expected ED50 is 10-30 ng/mL.
Expression host is Human HEK293 cells
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Purity||≥95%, Endotoxin ≤0.01EU/ug|
|Storage||2-8°C, dry, sealed|
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