All AbMole products are for research use only, cannot be used for human consumption.
Species: Mouse
Expression system: E. coli
Purity: SDS-PAGE analysis > 97%, HPLC analysis > 97%
Endotoxin: protein content < 1 EU/μg by LAL method
Theoretical molecular weight: 8 kDa
Storage and stability: After receiving, the product remains stable at -70°C or -20°C for up to 6 months. After recombination, the product should be stable at 4°C for 1 week or -20°C for 3 months. Avoid repeated freeze-thaw cycles.
Bioactivity: Fully bioactive compared to the standard. The bioactivity measured by chemotactic bioassay of human peripheral blood monocytes was in the range of 50.0-100.0 ng/ mL. Sdf-1 α and SDF-1β cdna encode precursor proteins with 89 and 93 amino acid residues, respectively. Both SDF-1α and SDF-1β are encoded by a single gene and produced by alternate splicing. The two proteins are identical except that sdF-1 β carboxyl terminus contains four amino acid residues and SDF-1α is absent. Sdf-1 /PBSF is highly conserved between species, with only one amino acid substitution between mature human and mouse proteins. Sdf-1 /PBSF works via chemokine receptor CXCR4 and has been shown to act as a chemokine for T lymphocytes, monocytes, pre-B cells, and pre-B cells, but not neutrophils. Mice lacking SDF-1 or CXCR4 were found to have impaired B lymphogenesis, bone marrow formation, vascular development, cardiogenesis, and abnormal nerve cell migration and patterns in the central nervous system.
| Solubility (25°C) | Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage |
Stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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