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Recombinant Mouse Sclerostin (HEK293, C-6His)

Cat. No. M43960

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse Sclerostin (HEK293, C-6His) Structure
Synonym:

SOST

Size Price Availability Quantity
10ug USD 270  USD270 In stock
50ug USD 735  USD735 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Sclerostin, also known as SOST, is a member of the Cerberus/DAN family of BMP antagonists. SOST has anti-anabolic effects on bone formation. SOST is an important regulator of bone homeostasis. SOST plays a physiological role as a negative regulator of bone formation by repressing BMP-induced osteogenesis.

Recombinant Mouse Sclerostin expressed the target gene encoding Gln24-Tyr211 with a 6His tag at the C-terminus.


Accession: Q99P68

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 32 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Luyao Wang, et al. Theranostics. Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice

[2] Timothy Dreyer, et al. J Orthop Translat. Recombinant sclerostin inhibits bone formation in vitro and in a mouse model of sclerosteosis

[3] Fuming Zhang, et al. Glycoconj J. Interactions between Sclerostin and Glycosaminoglycans

[4] Maarten van Dinther, et al. PLoS One. Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling

[5] Matthew D Kwan, et al. Plast Reconstr Surg. Differential expression of sclerostin in adult and juvenile mouse calvariae

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Keywords: Recombinant Mouse Sclerostin (HEK293, C-6His), SOST supplier, Cytokines and Growth Factors, inhibitors, activators

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