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R-Spondin-1 (Rspo-1) is a secreted protein,containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
R-Spondin-1 (Rspo-1) acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.
The recombinant mouse RSPO1 comprises 256 amino acids with a predicted molecular mass of 28.5 kDa.
Measured by the ability to induce activation of β-catenin response in a Topflash Luciferase assay using HEK293T human embryonic kidney cells, the ED50 is typically 0.1-0.9 μg/ml in the presence of 5 ng/mL recombinant mouse Wnt3a.
Endotoxin < 1.0 EU/μg
Lyophilized from sterile PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml. |
| Storage | Stable for up to 12 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
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Products are for research use only. Not for human use. We do not sell to patients.
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