Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase of the protease K family. PCSK9 binds to low density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in neural development. PCSK9 undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions.
Immobilized Recombinant Mouse PCSK9-His(Cat#M21547) at 2μg/ml (100 μl/well) can bind Biotinylated Human LDL R-His-Avi, the ED50 of Biotinylated Human LDL R-His-Avi is 0.301 ug/ml.
Recombinant Mouse Proprotein Convertase Subtilisin/Kexin Type 9 expressed the target gene encoding Gln35-Gln155&Ser156-Gln694 with a 6His tag at the C-terminus.
Accession: Q80W65
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 19&60 KDa, reducing conditions
Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.
The product is shipped on dry ice packs. Upon receipt, store it immediately at the temperature listed below.
| Form | Solution |
| Storage | Store at ≤ -70°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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