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Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Noggin binds some BMPs such as BMP4 with high affinity and others such as BMP7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors. It antagonizes the biological activity of BMP by blocking epitopes required on BMP to bind to type I and type II receptors. Noggin is expressed in specific regions of the central nervous system and surrounding tissues such as lung, skeletal muscle and skin in adults. When human embryonic stem cells (hESC) or neural stem cells (NSCS) were cultured under certain conditions, Noggin antagonized BMP activity could induce stem cells to remain undifferentiated and proliferate or differentiate into dopaminergic neurons.
Recombinant Mouse Noggin expressed the target gene encoding Gln28-Cys232 with a 6His tag at the C-terminus.
Lyophilized from a 0.2 μm filtered solution of PBS, 5mM EDTA, 5% Trehalose, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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