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Recombinant Mouse Interleukin-4 (IL-4) (E. coli)

Cat. No. M10466
Recombinant Mouse Interleukin-4 (IL-4) (E. coli) Structure
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5ug USD 115.2  USD128 In stock
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Quality Control
  • Current batch:
  • Purity >97%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Mouse Interleukin-4 is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It is produced by mast cells, activated T cells and bone marrow stromal cells. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. 

The ED50 as determined by the dose-dependant prolifiration of Murine HT-2 cells is less then 2 ng/ml, corresponding to a Specific Activity of > 5 × 105 IU/mg. 

Source: Escherichia coli. 

Molecular Weight: Approximately 13.5 kDa, a single non-glycosylated polypeptide chain containing 121 amino acids. 


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
CAS Number
Purity >97%, Endotoxin < 1 EU/μg
Solubility Reconstitute in sterile distilled water or aqueous buffer
Storage at -20°C

High level expression and refolding of mouse interleukin 4 synthesized in Escherichia coli
A D Levine, et al. J Biol Chem. 1995 Mar 31;270(13):7445-52. PMID: 7706290.

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Keywords: Recombinant Mouse Interleukin-4 (IL-4) (E. coli) supplier, Cytokines, inhibitors

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