Free shipping on all orders over $ 500

Recombinant Mouse Interleukin-4 (IL-4) (E. coli)

Cat. No. M10466
Recombinant Mouse Interleukin-4 (IL-4) (E. coli) Structure
Size Price Availability Quantity
5ug USD 115.2  USD128 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >97%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Mouse Interleukin-4 is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It is produced by mast cells, activated T cells and bone marrow stromal cells. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. 

The ED50 as determined by the dose-dependant prolifiration of Murine HT-2 cells is less then 2 ng/ml, corresponding to a Specific Activity of > 5 × 105 IU/mg. 

Source: Escherichia coli. 

Molecular Weight: Approximately 13.5 kDa, a single non-glycosylated polypeptide chain containing 121 amino acids. 

Sequence: MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >97%, Endotoxin < 1 EU/μg
Solubility Reconstitute in sterile distilled water or aqueous buffer
Storage at -20°C
References

High level expression and refolding of mouse interleukin 4 synthesized in Escherichia coli
A D Levine, et al. J Biol Chem. 1995 Mar 31;270(13):7445-52. PMID: 7706290.

Related Cytokines Products
Recombinant human VEGF-C (HEK 293)

Recombinant human VEGF-C (rhVEGF-C) is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels.

Recombinant Human Interleukin-31 (E. coli)

Recombinant Human Interleukin-31 (IL-31) signals through IL-31 receptor A and oncostatin M receptor subunits and can activate STAT3 through receptors and maybe involve in skin immunity.

Recombinant Human Interleukin-6 (E. coli)

Recombinant Human IL-6 is an interleukin that in humans is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine.

Recombinant Mouse Interleukin-4 (IL-4) (CHO-expressed)

Recombinant Mouse Interleukin-4 is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression.

Recombinant Rat Insulin-like Growth Factor-1 (E. coli)

Recombinant Rat Insulin-like Growth Factor-1 belonged to the insulin gene family, it is mitogenic polypeptide growth factor that stimulates the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Recombinant Mouse Interleukin-4 (IL-4) (E. coli) supplier, Cytokines, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.