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Recombinant Mouse Interleukin-4 (IL-4) (CHO-expressed)

Cat. No. M10465
Recombinant Mouse Interleukin-4 (IL-4) (CHO-expressed) Structure
Synonym:

rMuIL-4

Size Price Availability Quantity
10ug USD 180  USD200 In stock
50ug USD 540  USD600 In stock
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Quality Control
  • Current batch:
  • Purity >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Mouse Interleukin-4 is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It is produced by mast cells, activated T cells and bone marrow stromal cells. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. 

ED50 < 2 ng/ml, measured in a cell proliferation assay using murine HT-2 cells, corresponding to a specific activity of >5 x 105 units/mg. 

Sequence:  HIHGCDKNHL REIIGILNEV TGEGTPCTEM DVPNVLTATK NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR LFRAFRCLDS SISCTMNESK STSLKDFLES LKSIMQMDYS

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95%, Endotoxin < 0.2 EU/μg
Solubility Reconstituted in ddH2O or PBS at 100 μg/ml
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Recombinant Mouse Interleukin-4 (IL-4) (CHO-expressed), rMuIL-4 supplier, Cytokines, inhibitors

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