All AbMole products are for research use only, cannot be used for human consumption.
Species: Mouse
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/ug (1 EU/ug) as tested by LAL
Redissolve: centrifuge the tube before opening it. Do not mix by eddy current or pipette. Recombination to concentrations below 100 μg/ mL is not recommended. Lyophilized egg whites are dissolved in distilled water. Separate the reformulated solution to reduce freeze-thaw cycles.
Storage and stability: Lyophilized proteins should be stored at < -20°C but can be stored at room temperature for up to 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The isometric solution of the recombinant sample was stable at < -20°C for 3 months.
Biological activity: IL-36B is synthesized in a variety of cells, including resting and active monocytes and B cells. The receptor for IL-36 β is thought to bind IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 β is a part of the IL-36 signaling system and is believed to exist in the epithelial barrier and participate in local inflammatory responses. Similar to the IL-1 system, it is shared with the coreceptor IL1RAP. In addition, interleukin 36 β may be involved in skin inflammation, act on keratinocytes, dendritic cells, and indirectly on T cells, promoting tissue infiltration, cell maturation, and cell proliferation. T promoter 1 (Th1) cells, cultured CD4+ T cells, and spleen cells stimulate the surface expression of CD80, CD86, and MHC class II, and induce the production of IFN - γ, IL-4, and IL-17, which play an important role in dendritic cell maturation.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100 μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cytokines and Growth Factors Products |
|---|
| Recombinant Human GDF-15 Protein (HEK293 N-hFc)
Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily. GDF-15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
| Recombinant Human FGFR1 Protein (HEK293, C-His)
FGFR1, also known as CD331, is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. |
| Recombinant Human FGFR2 Protein (HEK293, C-His)
FGFR2, also known as CD332, acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. |
| Recombinant Mouse BMP-4 Protein (E. coli, C-His)
Bone Morphogenetic Protein-4 (BMP-4) is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP-4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog to establish a dorsal-ventral axis for the differentiation of later structures. |
| Recombinant Human Coagulation Factor X (HEK293, C-Fc)
Coagulation factor X, belongs to the peptidase S1 family. Coagulation factor X is initially synthesized in the liver. Coagulation factor X is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
