All AbMole products are for research use only, cannot be used for human consumption.
Species: Mouse
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/ug (1 EU/ug) as tested by LAL
Redissolve: centrifuge the tube before opening it. Do not mix by eddy current or pipette. Recombination to concentrations below 100 μg/ mL is not recommended. Lyophilized egg whites are dissolved in distilled water. Separate the reformulated solution to reduce freeze-thaw cycles.
Storage and stability: Lyophilized proteins should be stored at < -20°C but can be stored at room temperature for up to 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The isometric solution of the recombinant sample was stable at < -20°C for 3 months
Biological activity: Il36a is a cytokine that binds and signals through the IL1RL2/IL-36R receptor to activate the NF-Kappa-B and MAPK signaling pathways in target cells associated with pro-inflammatory responses. It is part of the IL-36 signaling system and is thought to exist in the epithelial barrier and participate in local inflammatory responses; Similar to the IL-1 system, it is shared with the coreceptor IL1RAP. It appears to drive tissue infiltration, cell maturation, and cell proliferation by acting on keratinocytes, dendritic cells, and indirectly on T cells, and is involved in skin inflammation. Inducing bone marrow derived dendritic cells (BMDCs) to produce pro-inflammatory cytokines IL-12, IL-1 β, IL-6, TNF - α and IL-23. It is involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II, and induces the production of IFN - γ, IL-4 and IL-17 by cultured CD4+ T cells and spleen cells.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100 μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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