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Interleukin-21 (IL-21) is a approximately 14kda cytokine belonging to the IL-15/IL-21 family. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It plays its biological role through the heterodimer receptor complex (IL-21 specific il-21r). IL-21 is a cytokine that has a powerful regulatory effect on the cells of the immune system, including natural killer cells (NK) and cytotoxic T cells that can destroy viral infections or cancer cells. This cytokine induces cell division/proliferation in target cells. It is required for the migration of dendritic cells to draining lymph nodes, and it jointly stimulates the activation, proliferation and survival of CD8+ T cells and NKT cells, and promotes the polarization of Th17 cells. It blocks the production of regulatory T cells and its inhibitory effect on CD4+ T cells.
Accession: Q9ES17
APMol Mass: 16 KDa, reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl, 6% Sucrose, 2% Glycine, 50mM NaCl, 0.05% Tween 80, pH 6.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months. |
[1] Anusha Kalbasi, et al. Nature. Potentiating adoptive cell therapy using synthetic IL-9 receptors
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Products are for research use only. Not for human use. We do not sell to patients.
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