Species: Mouse
Expression system: Mammalian
Endotoxin: LAL test measured less than 0.1 ng/µg (1eu /µg)
Storage and stability: Freeze-dried protein should be stored at < -20℃, but stable at room temperature for 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The bisector of the recombinant sample was stable at < -20°C for 3 months.
Molecular weight: 45.5 KDa
Biological activity: Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity interleukin-15 receptor. Il15ra binds as a heterotrimer to IL-2 receptor β and γ subunit (ordinary γ chain or γ c) to initiate signal transduction. It can emit both cis and trans signals, in which IL15R from a subset of cells expresses IL15 to neighboring cells that express il2rg. Il15ra is expressed in specialized cells, including a variety of t cells, B cells and non-lymphocyte. The human Il15ra has 45% amino acid sequence homology with the murine form of the receptor. Eight isomers of il-15rα mRNA have been identified, caused by alternative splicing events involving different exons.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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