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Recombinant Mouse IL-15RA (HEK293, C-Fc)

Cat. No. M21448

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse IL-15RA (HEK293, C-Fc) Structure
Synonym:

Interleukin-15 receptor subunit alpha

Size Price Availability Quantity
10ug USD 150  USD150 In stock
50ug USD 330  USD330 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin<1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Mouse
Expression system: Mammalian
Endotoxin: LAL test measured less than 0.1 ng/µg (1eu /µg)
Storage and stability: Freeze-dried protein should be stored at < -20℃, but stable at room temperature for 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The bisector of the recombinant sample was stable at < -20°C for 3 months.
Molecular weight: 45.5 KDa



Biological activity: Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity interleukin-15 receptor. Il15ra binds as a heterotrimer to IL-2 receptor β and γ subunit (ordinary γ chain or γ c) to initiate signal transduction. It can emit both cis and trans signals, in which IL15R from a subset of cells expresses IL15 to neighboring cells that express il2rg. Il15ra is expressed in specialized cells, including a variety of t cells, B cells and non-lymphocyte. The human Il15ra has 45% amino acid sequence homology with the murine form of the receptor. Eight isomers of il-15rα mRNA have been identified, caused by alternative splicing events involving different exons.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yanli Pan, et al. Curr Mol Med. Schizophrenia Patient Shows a Rare Interleukin 15 Receptor alpha Variant Disrupting Signal Transduction

[2] Jesse Rowley, et al. Eur J Immunol. Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cis

[3] Jesse Rowley, et al. J Immunol. Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans

[4] Xiaogang Du, et al. J Gene Med. The adjuvant effects of co-stimulatory molecules on cellular and memory responses to HBsAg DNA vaccination

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Keywords: Recombinant Mouse IL-15RA (HEK293, C-Fc), Interleukin-15 receptor subunit alpha supplier, Cytokines and Growth Factors, inhibitors, activators

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