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Recombinant Mouse IL-10 (CHO)

Cat. No. M15109
Recombinant Mouse IL-10 (CHO) Structure
Synonym:

Mouse Interleukin-10 Protein

Size Price Availability Quantity
10ug USD 250  USD250 In stock
50ug USD 750  USD750 In stock
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Quality Control
  • Current batch:
  • Purity >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Mouse IL-10 (CHO) belongs to the IL-10 family and shares more than 80% sequence homology with the Epstein-Barr Virus protein BCRFI. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF, by activated macrophages and Th2 cells. Recombinant Mouse IL-10 also displays the ability to suppress Antigen-Presenting Cell (APC) function. 

ED50 < 0.2 ng/ml, measured in a cell proliferation assay using MC/9 cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95%, Endotoxin < 0.2 EU/μg
Solubility Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml
Storage at -20°C
References

[1] Mira Jung, et al. Basic Res Cardiol. IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation

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