Recombinant Mouse IL-10 (CHO) belongs to the IL-10 family and shares more than 80% sequence homology with the Epstein-Barr Virus protein BCRFI. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF, by activated macrophages and Th2 cells. Recombinant Mouse IL-10 also displays the ability to suppress Antigen-Presenting Cell (APC) function.
ED50 < 0.2 ng/ml, measured in a cell proliferation assay using MC/9 cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Purity||>95%, Endotoxin < 0.2 EU/μg|
|Solubility||Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml|
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