All AbMole products are for research use only, cannot be used for human consumption.
Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. GDNF promotes the survival and differentiation of dopaminergic neurons and increases their high affinity for dopamine uptake. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. In a mouse Parkinson’s Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability.
Recombinant Mouse GDNF expressed the target gene encoding Met77-Ile211.
Measured in a bioassay using C6 cells, the ED50 is < 8.0 μg/ml.
Accession: P48540
Endotoxin < 0.2 EU/µg
Apparent Molecular Weight: 17~22 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[5] Jun Kawanokuchi, et al. J Neuroimmunol. Production and functions of IL-17 in microglia
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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