Species: Mouse
Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: less than 0.001 ng/ug (0.01 EU/ug) as determined by LAL
Storage and stability: storage temperature ≤-70℃, after receiving the goods can be stably stored for 6 months. After opening, store in aseptic condition for 3 months, storage temperature ≤-70℃. Please minimize freeze-thaw cycles.
Bioactivity: Fibroblast growth factor-9 (FGF-9) is a glycoprotein of the FGF-family secreted about 26 kDa. Secreted mouse FGF-9 lacks n-terminal 1-3-AA and shares >98% sequence consistency with FGF-9 of rats, humans, horses, pigs and cattle. Fgf-9 plays an important role in regulating embryonic development, cell proliferation, cell differentiation and cell migration. In embryonic mice, FGF expression - 9 position and time affect bones, cerebellum, lungs, heart, blood vessels, gastrointestinal tract and testicular development, may in the development of glial cells in the process of growth and differentiation, in the process of repair and regeneration after injury of brain tissue glial cell proliferation, differentiation and survival of neurons, and glial tumor growth stimulation and so on. Fgf-9 deletion in mice is fatal at birth due to lung hypoplasia and leads to root-like protuberances or shortening of proximal bones. An unusual compositional dimer of FGF 9 obsures the receptor's interaction site, thereby reducing its activity and increasing the affinity of heparin, thereby inhibiting diffusion. Eks, a spontaneous mutant in mice, interferes with dimerization and produces monomer, diffusible FGF-9. Misexpression of FGF-9 in developing joints leads to elbow and knee slippage (joint fusion).
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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