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Recombinant Mouse FGF-4 (E.coli)

Cat. No. M15068
Recombinant Mouse FGF-4 (E.coli) Structure
Synonym:

Fibroblast growth factor 4; FGF-4; Heparin secretory-transforming protein 1

Size Price Availability Quantity
10ug USD 160  USD160 In stock
50ug USD 400  USD400 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 0.01 EU/ug
  • COA
  • MSDS
Biological Activity

Species: Mouse
Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: less than 0.001 ng/ug (0.01 EU/ug) as determined by LAL
Storage and stability: Lyophilized proteins should be stored at < -20°C but can be stored at room temperature for up to 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The isometric solution of the recombinant sample was stable at < -20°C for 3 months.


Bioactivity: Fibroblast growth factor 4(FGF-4) is a heparin-binding member of the FGF family. Human FGF4 cDNA encodes 206 amino acids (AA), including 33 signal sequences and 173 mature proteins, with a FGF homologous domain containing a heparin binding region near the C-terminal. The homology of mature human FGF4 with mouse, rat, dog and bovine FGF4 was 91%, 82%, 94% and 91%, respectively. Human FGF-4 has been shown to have cross-species activity. The expression of FGF-4 and its receptors, FGF R1c, 2C, 3C and 4, are spatio-temporal regulated during embryonic development. Fgf-4 is thought to play a physiologically relevant role in the self-renewal of human embryonic stem cells. It promotes stem cell proliferation, but may also aid differentiation depending on environment and concentration, and is often included in embryonic stem cell culture medium in vitro. In vitro, FGF-4 is a mitotic source of fibroblasts and endothelial cells and has the potential of autocrine transformation.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] V Libri, et al. FEBS Lett. The artificial zinc finger protein 'Blues' binds the enhancer of the fibroblast growth factor 4 and represses transcription

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Keywords: Recombinant Mouse FGF-4 (E.coli), Fibroblast growth factor 4; FGF-4; Heparin secretory-transforming protein 1 supplier, Recombinant Proteins, inhibitors, activators


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