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Recombinant Mouse FABP4 Protein (HEK293, C-His)

Cat. No. M54561
Recombinant Mouse FABP4 Protein (HEK293, C-His) Structure
Synonym:

A-FABP; ALBP

Size Price Availability Quantity
100ug USD 800  USD800 In stock
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Quality Control & Documentation
  • Purity: >90%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

FABP4 is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations and blood pressure.

The recombinant mouse FABP4 comprises 143 amino acids and has a calculated molecular mass of 16 kDa. A DNA sequence encoding the mouse FABP4 (Met 1-Ala 132) is expressed with a C-terminal polyhistidine tag.


Endotoxin < 1 EU/µg

Apparent Molecular Weight: ~15 kDa, reducing conditions

Lyophilized from sterile PBS, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Mouse FABP4 Protein (HEK293, C-His), A-FABP; ALBP supplier, Recombinant Proteins, inhibitors, activators


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