Species: Mouse
Expression system: CHO
Purity: sdS-PAGE analysis result was 98%
Endotoxin: protein < 0.2 EU/μg was determined by gel coagulation
Apparent molecular weight: ~ 8kda, sds-page under reduction conditions
Storage and stability: After receiving, the product remains stable at temperatures below -70°C for up to 6 months. After recombination, the product should be stable at 4°C for 1 week or -20°C for 3 months. For long-term preservation, carrier protein (e.g. 0.1% BSA) is recommended. Avoid repeated freeze-thaw cycles.
Biological activity: The EC50 value of MOUSE DCIP-1/CXCL3 against Cho-K1 /Ga15/mCXCR2 cells (human Ga15 and mouse CXCR2 were stably expressed in Cho-K1 cells) was less than 100.0 ng/ mL. CXCL3 controls monocyte migration and adhesion by interacting with the cell surface chemokine receptor CXCR2 and mediates its effect on target cells. Studies have shown that CXCL3 regulates the migration of cerebellar granular neuron precursors to the inner cerebellar layer during morphogenesis.
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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