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Recombinant Mouse CXCL1/GRO-α/KC (CHO)

Cat. No. M21438

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse CXCL1/GRO-α/KC (CHO) Structure
Size Price Availability Quantity
5ug USD 138  USD138 In stock
25ug USD 220  USD220 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Mouse CXCL1/GRO-α is a potent neutrophil attractant and activator. CXCL1 was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease.

Active at 10.0 ng/ml, measured in a tube formation assay using HUVEC cells.

Species: Mouse

Expression System: CHO

Endotoxin Level: < 0.2 EU/μg of protein by gel clotting method

Apparent Molecular Weight: 5~7 kDa, on SDS-PAGE under reducing conditions.

Formulation: Lyophilized after extensive dialysis against PBS.

Storage & Stability: Upon receiving, this product remains stable for up to 12 months at lower than -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lela Stefanovic, et al. Exp Biol Med (Maywood). Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils

[2] J Witowski, et al. J Immunol. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells

[3] E Loukinova, et al. Oncogene. Growth regulated oncogene-alpha expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC receptor-2 dependent mechanism

[4] J N Heinrich, et al. J Biol Chem. The orphan mouse receptor interleukin (IL)-8R beta binds N51. Structure-function analysis using N51/IL-8 chimeric molecules

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Keywords: Recombinant Mouse CXCL1/GRO-α/KC (CHO) supplier, Cytokines and Growth Factors, inhibitors, activators

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