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Recombinant Mouse CXCL1/GRO-α/KC (CHO)

Cat. No. M21438

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse CXCL1/GRO-α/KC (CHO) Structure
Size Price Availability Quantity
5ug USD 120 In stock
25ug USD 220 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Mouse CXCL1/GRO-α is a potent neutrophil attractant and activator. CXCL1 was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease. CXCL1 is a potent neutrophil attractant and activator. The functional receptor for CXCL1 has been identified as CXCR2.

Recombinant Mouse CXCL1 expressed the target gene encoding Ala25-Lys96.

Measure in a tube formation assay using HUVEC cells, the activity for this effect is 10.0 ng/mL.


Accession: P12850

Apparent Molecular Weight: 5~7 kDa, under reducing conditions

Endotoxin < 0.2 EU/µg

Tag Info: Tag free

Lyophilized from a 0.2 μm filtered solution of of PBS, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Lela Stefanovic, et al. Exp Biol Med (Maywood). Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils

[2] J Witowski, et al. J Immunol. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells

[3] E Loukinova, et al. Oncogene. Growth regulated oncogene-alpha expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC receptor-2 dependent mechanism

[4] J N Heinrich, et al. J Biol Chem. The orphan mouse receptor interleukin (IL)-8R beta binds N51. Structure-function analysis using N51/IL-8 chimeric molecules

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Keywords: Recombinant Mouse CXCL1/GRO-α/KC (CHO) supplier, Cytokines and Growth Factors, inhibitors, activators

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