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Recombinant Mouse BAFF (TNFSF13B/TNFSF20) belongs to the tumor necrosis factor family. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. The target gene encoding Ala127-Leu309 is expressed with a mFc tag at the N-terminus. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3 acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Accession: Q9WU72
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Solubility (25°C) | Reconstitute the lyophilized protein in distilled water at 100 μg/ml |
| Storage | Stored at ≤ -20°C, stable for one year after receipt |
[3] Kathrin Pieper, et al. J Allergy Clin Immunol. B-cell biology and development
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