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Recombinant Mouse Apolipoprotein E (Mammalian, C-6His)

Cat. No. M45091
Recombinant Mouse Apolipoprotein E (Mammalian, C-6His) Structure
Synonym:

Apo-E; APOE

Size Price Availability Quantity
10ug USD 180  USD180 In stock
50ug USD 660  USD660 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Apolipoprotein E (Apo-E) is a member of the apolipoprotein A1/A4/E family. APOE may function in mediating the binding, internalization, and catabolism of lipoprotein particles. Apolipoprotein E (Apo-E) can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. 

Recombinant Mouse Apolipoprotein E expressed the target gene encoding Glu19-Gln311 with a 6His tag at the C-terminus. 


Accession: P08226

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 30-40 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Mouse Apolipoprotein E (Mammalian, C-6His), Apo-E; APOE supplier, Recombinant Proteins, inhibitors, activators


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