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Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system. The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. Angiopoietin-1 can protect against pulmonary arterial hypertension, reduce the extent of fibrosis and remodeling in infarcted diabetic myocardium, and enhance tumor progression and metastasis.
A DNA sequence encoding the mouse Angpt1 (NP_033770.2) (Arg277-Phe498) was expressed with a polyhistidine tag at the N-terminus.
The recombinant mouse Angpt1 consists 241 amino acids and predicts a molecular mass of 28 kDa.
Lyophilized from sterile PBS, pH 7.4.
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH₂O or PBS to 100 μg/ml |
| Storage | Stable for up to twelve months from date of receipt at -20℃ to -80℃ |
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